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Lipid nanoparticles (LNPs) have achieved prominence primarily due to their vital role in the delivery of mRNA-based vaccines, like those developed for COVID-19. This application has catalyzed vast investment and research, propelling the growth in the LNP market. The pharmaceutical sector is the largest end-user of LNPs. These nanoparticles are important in drug delivery systems due to their capability to encapsulate and protect drugs, particularly RNA-based therapeutics, improving their bioavailability and stability. Regionally, North America holds the largest share of the market, attributed to developed healthcare infrastructure, significant investments in R&D, and the presence of leading pharmaceutical companies.
Europe follows closely, pushed by similar factors. Asia-Pacific is appearing as a fast-growing region in the LNP market, thanks to the rising healthcare expenditure, increasing pharmaceutical industries in countries like India and China, and rising government initiatives in biotechnology research. In addition to this, according to the research report of Astute Analytica, the global lipid nanoparticle market is growing at a compound annual growth rate (CAGR) of 12.6% during the forecast period from 2024 to 2032. The Role of Lipid Nanoparticles Application in mRNA Vaccination is: -
Lipid nanoparticle (LNP) technology is essential to the advancement of mRNA vaccines. However, most studies concentrate on technical aspects and neglect the patent landscape. Moreover, there is a lack of differentiation of LNP technology distinctions among mRNA, mRNA vaccines, and COVID-19 mRNA vaccines, leading to confusing comparisons.
In recent years, mRNA-based vaccines have revolutionized immunization by using messenger RNA (mRNA) to instruct cells in delivering certain antigens and triggering a protective immune response against infectious diseases. However, the inherent instability of mRNA vaccines remains a challenge. To handle this, lipid nanoparticle (LNP) technology has appeared as a promising delivery system for mRNA vaccines.
LNP serves as a “Trojan horse,” stabilizing mRNA and enabling its safe delivery into cells to improve the body’s immune response. This technology has shown remarkable success in COVID-19 vaccines and has huge potential to combat different diseases, cancers, and other medical applications. The current market for LNP-enabled in vivo genomic medicine market is valued at US$ 51 billion.
Despite the possibility of mRNA vaccines and LNP delivery technology in combating COVID-19, there are limited analyses of journal articles and patents that incorporate both technologies. Moreover, the absence of distinction between the usage of LNP in mRNA vaccines, mRNA, and COVID-19 vaccines leads to confusion and makes comparisons difficult.
This review desires to clarify the developmental relationships between LNP applications in mRNA vaccines, mRNA, and COVID-19 vaccines by analyzing journal publications and patents.
LNs are contemporary formulations that deliver much more flexibility in optimal release profile, drug loading, and enhanced efficacy in producing final dosage forms. The results acquired with their dermal application are encouraging, and presumably, this can be one of the main applications of LNs in the future. The excipients utilized for LN production have GRAS status, and most of them have already been integrated into pharmaceutical or food products.